In recent years, various silver ion preparations and silver ion dressings have been widely used in the treatment of acute and chronic wounds such as burns. Because silver ion has good antibacterial properties, it has been widely recognized by medical institutions.
In fact, as early as 5,000 years ago, the separation and smelting technology of metallic silver already existed, and in the process of gradual development, everyone discovered various characteristics of metallic silver, including the anti-infection effect of metallic silver on the wound surface. Silver is a natural antibacterial material that has been used by humans for thousands of years. Silver has a broad antibacterial spectrum and is not easy to produce drug resistance. Silver can reduce the bacterial load on the wound, accelerate wound healing, and treat infections. It can also be used for wound dressings, infusion tubes, etc. It is mainly used for the treatment of chronic wounds, and is often used for postoperative injury and repair.
Applying silver-containing antibacterial materials to wound dressings can effectively solve the problem of delayed wound healing caused by bed sores, diabetic wounds, arteriovenous ulcer wounds, burns and scalds.
The main dressing matrices of silver-containing dressings are: medical degreased cloth, non-woven cloth, polymer materials, carbon fiber, hydrogel, sodium alginate, etc. The physical properties of different matrices such as water absorption, moisture retention, and air permeability are different. Clinicians should choose the appropriate silver-containing dressing according to the different needs of the wound. Silver has broad-spectrum antibacterial properties, which can kill almost all common bacteria and has a certain effect on fungi.
The antibacterial mechanisms of silver ions and their compounds mainly include:
1) Silver ions combine with negatively charged bacteria to increase the permeability of the bacterial outer membrane and induce bacterial apoptosis;
2) Silver ions enter the bacteria and interact with bacteria. Enzyme interaction. The active sulfhydryl groups and amino groups on the protein combine to inactivate the enzyme protein, thereby interfering with the energy metabolism of bacteria and inhibiting the growth and reproduction of bacteria;
3) Silver ions bind to bacterial DNA or RNA to prevent its replication and destroy the ability of bacteria to reproduce, thereby Play a role in inhibiting or killing bacteria;
4) inhibit the formation of bacterial biofilm.
Biofilm is an important environmental adaptation mechanism for bacteria. Once formed, drugs or other antibacterial products are difficult to remove. Composite or silver plating on the surface of medical materials is beneficial to inhibit the formation of bacterial biofilm.http://www.china-medicaldressing.com
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